{"id":9187,"date":"2025-01-07T16:15:27","date_gmt":"2025-01-07T21:15:27","guid":{"rendered":"https:\/\/latinamericasecurityreport.com\/?p=9187"},"modified":"2025-01-07T16:15:27","modified_gmt":"2025-01-07T21:15:27","slug":"compound-derived-from-brazilian-plant-exhibits-action-against-parasite-that-causes-visceral-leishmaniasis","status":"publish","type":"post","link":"https:\/\/latinamericasecurityreport.com\/?p=9187","title":{"rendered":"Compound Derived from Brazilian Plant Exhibits Action Against Parasite That Causes Visceral Leishmaniasis"},"content":{"rendered":"
Electron microscope image of Leishmania, structure of synthetic compound, and rat<\/figcaption><\/figure>\n

A compound derived from\u00a0Nectandra leucantha<\/em>, a tree native to southern Brazil (local names\u00a0canela-seca<\/em>\u00a0or\u00a0canela-branca<\/em>), has the potential to be used to treat visceral leishmaniasis, a neglected tropical disease associated with poverty, malnutrition, poor housing and lack of basic sanitation.<\/p>\n

The disease is almost always fatal if left untreated. Most cases occur in Brazil, East Africa and India, according to the World Health Organization (WHO). An estimated 50,000-90,000 new cases and 20,000-50,000 deaths occur worldwide annually, with only 25%-45% of cases being reported to WHO.<\/p>\n

The disease is caused by a protozoan parasite transmitted by sandfly bite, and characterized by long bouts of fever, loss of weight and muscle strength, enlargement of the spleen and liver, and anemia.<\/p>\n

An article by researchers affiliated with institutions in Brazil, the United Kingdom and Portugal,\u00a0published<\/strong><\/a>\u00a0in the journal\u00a0Antimicrobial Agents and Chemotherapy<\/em>, reports the findings of a study showing that the substance killed\u00a0Leishmania infantum<\/em>, the parasite that causes the disease, selectively (i.e. without affecting host cells).<\/p>\n

The first step in the study, which was\u00a0supported by FAPESP<\/a><\/strong>, was synthesis of a compound similar to dehydrodieugenol B, a neolignan found naturally in\u00a0N. leucantha<\/em>\u00a0and isolated originally by Jo\u00e3o Lago, full professor at the Federal University of the ABC (UFABC) in S\u00e3o Paulo state, Brazil. The synthesis was performed by Edward Anderson, a professor of organic chemistry at the University of Oxford in the UK.<\/p>\n

\u201cWe used this substance as a prototype, a model based on which we could design novel versions of the molecule [with minor structural variations<\/em>] and test them one by one on the parasite in vitro with the aim of optimizing its action,\u201d said\u00a0Andr\u00e9 Gustavo Tempone<\/strong><\/a>, principal investigator for the study and a researcher at Butantan Institute\u2019s Physiopathology Laboratory in Brazil.<\/p>\n

In this manner, the researchers obtained a molecule four times more powerful than the prototype. However, in vivo tests involving animals were disappointing because the optimized compound circulated in the rodents\u2019 organism for less than ten minutes, and the study was unable to make progress. \u201cThe fact that the substance circulated for such a short time in the rats\u2019 bodies suggested that the ensuing stages of the research would fail. It became clear that the substance wouldn\u2019t produce the expected results,\u201d Tempone said.<\/p>\n

The team then focused on additional optimization of the molecule with the aim of enhancing its bioavailability so that it would remain for longer in the animal\u2019s organism. After several chemical optimization processes conducted in vitro in partnership with Maiara Amaral, a student of Tempone\u2019s who was on an internship at Oxford University and used the project as her PhD thesis, they arrived at a more potent molecule whose mean plasma half-life reached 21 hours.<\/p>\n

Pharmacokinetic studies measuring the time required for the substance to be absorbed, distributed, metabolized and excreted showed that it circulated in the rat\u2019s organism for a period 100 times longer than that observed initially.<\/p>\n

Based on the in vitro analysis, the researchers concluded both that the novel substance was more potent in combating\u00a0L. infantum<\/em>, and that it did no damage to host cells. They also investigated its action mechanism, showing that it caused an irreversible collapse of the parasite\u2019s energy mechanism (ATP) due to an increase in calcium, while reducing host cell inflammation, a key factor in the treatment of visceral leishmaniasis. With these good results behind them, the scientists plan to advance farther in animal trials. \u201cWe need to analyze the action of the compound in rodents with leishmaniasis in order to assess its efficacy and the doses required for treatment,\u201d Tempone said.<\/p>\n

Their long-term goal is to use the compound to produce medications against visceral leishmaniasis, but a great deal of work still has to be done to achieve this objective. As Tempone recalled, novel drugs take around 15 years to come to market, the development process involving rigorous tests and trials to ensure that the active ingredient is totally safe before clinical trials involving humans can be approved.<\/p>\n

This research is extremely important, he added, as the large pharmaceutical companies are not interested in developing drugs for neglected diseases such as visceral leishmaniasis. \u201cBrazil has one of the most outstanding biodiversities in the world, and a huge abundance of available chemical structures that can be copied and used in medications. If we don\u2019t invest in combating this disease, the rich countries where it isn\u2019t endemic certainly won\u2019t,\u201d he said.<\/p>\n","protected":false},"excerpt":{"rendered":"

A compound derived from\u00a0Nectandra leucantha, a tree native to southern Brazil (local names\u00a0canela-seca\u00a0or\u00a0canela-branca), has the potential to be used to treat visceral leishmaniasis, a neglected tropical disease associated with poverty, malnutrition, poor housing and lack of basic sanitation. The disease is almost always fatal if left untreated. Most cases occur in Brazil, East Africa and…<\/p>\n","protected":false},"author":124,"featured_media":9188,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"fifu_image_url":"https:\/\/earimediaprodweb.azurewebsites.net\/Api\/v1\/Multimedia\/7ef1d16d-a822-4046-9fa5-f6c0e65b515b\/Rendition\/low-res\/Content\/Public","fifu_image_alt":"","footnotes":""},"categories":[195],"tags":[],"class_list":["post-9187","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-environment"],"_links":{"self":[{"href":"https:\/\/latinamericasecurityreport.com\/index.php?rest_route=\/wp\/v2\/posts\/9187","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/latinamericasecurityreport.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/latinamericasecurityreport.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/latinamericasecurityreport.com\/index.php?rest_route=\/wp\/v2\/users\/124"}],"replies":[{"embeddable":true,"href":"https:\/\/latinamericasecurityreport.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9187"}],"version-history":[{"count":1,"href":"https:\/\/latinamericasecurityreport.com\/index.php?rest_route=\/wp\/v2\/posts\/9187\/revisions"}],"predecessor-version":[{"id":9189,"href":"https:\/\/latinamericasecurityreport.com\/index.php?rest_route=\/wp\/v2\/posts\/9187\/revisions\/9189"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/latinamericasecurityreport.com\/index.php?rest_route=\/wp\/v2\/media\/9188"}],"wp:attachment":[{"href":"https:\/\/latinamericasecurityreport.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/latinamericasecurityreport.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/latinamericasecurityreport.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}